Kollidon SR is a physical mixture of polyvinyl acetate and polyvinylpyrrolidone (PVP; 8:2) prepared by direct compression, widely used for extended-release matrix tablets.13 They keep intact shape and dimensions passing through the gastric tract and facilitate the transport of the drug through the pores formed by PVP dissolution, in a diffusion-controlled manner. From the previous studies, it was found that water uptake rates in Kollidon SR matrices were very high at first media exposure, and then, they settled to a constant level when the matrix was completely soaked.15 Therefore, parameters such as pore sizes, Kollidon SR content, and matrix density principally regulate the release.
sejong tablet compression machine pdf 33
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The impact of the compression force on the crushing strength was extensively studied; in the present case it produced an increase in the crushing strength from 57.59.86 N to 384.520.48 N. In order to assess the influence of the compression force on the Pal release, dissolution tests were conducted on formulations with the same content (FI tablets, Table 3), but with increasing crushing strength. As expected, the higher the crushing strength, the slower the release, but it seems that if an average value of 350 N is attained, the influence of the crushing strength weakens, up to a limit where the dissolution profile is no longer affected (Figure 2B). In insoluble matrix-type tablets, drug release increases with the increase in initial porosity.23 Lactose, the water-soluble filler, quickly dissolves in the media, leaving the water-filled pores that easily allow Pal release by diffusion. The diffusion coefficient was reported to rise with higher initial porosity, which explains the result obtained for the dissolution profiles.13,23
The GKF Selection Series provides best conditions for state-of-the-art, flexible, and safe filling of capsules. It is capable of filling different types of products or combinations of products into hard shell capsules (HPMC or gelatin). Thanks to the modular assembly of the capsule filler, the machines can accommodate filling applications for (mini-) tablets, pellets, granules, liquids, or combinations. Quick changeover times and intuitive handling make the machines ideal for the production of pharmaceutical, health and nutrition products. 2ff7e9595c